GTU BE 6th Semester 2163605 Technology of Solid Dosage forms and Medicinal Natural Products Summer 2018 Question Paper

Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE – SEMESTER ?VI (NEW) – EXAMINATION ? SUMMER 2018
Subject Code: 2163605 Date: 08/05/2018
Subject Name: Technology of Solid Dosage forms & Medicinal Natural
Products
Time: 10:30 AM to 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) What is Comminution? Describe briefly the types involved? 03
(b) Discuss the advantages and disadvantages of tablet dosage form? 04
(c) List the problems associated with coated tablets? Briefly explain any seven of
them?
07
Q.2 (a) Write a note on Preformulation? 03
(b) Name two alkaloids present in PapaverSomniferum? Write short notes on them? 04
(c) What are the major types of Tannins? Which tests are done to identify Tannins? 07
OR
(c) Describe the isolation &synthesis of Caffeine or Nicotine? 07
Q.3 (a) Briefly describe the different methods of tablet coating. 03
(b) Describe the steps involved in tableting method using wet granulation? 04
(c) Illustrate the different types of Pharmaceutical factory layouts? 07
OR
Q.3 (a) What is roller compaction& slugging? 03
(b) What are the tests done for detection of cardiac glycosides? 04
(c) Explain counter current extraction? Discuss any two counter current extractors? 07
Q.4 (a) How is Morphine converted to Codeine? 03
(b) What are the main tests for identification of Alkaloids? 04
(c) Describe how Phenylalanine and Tyrosine are made from Shikkimic acid
pathway biosynthetically?
07
OR
Q.4 (a) Describe Shikimate pathway or Mevalonate pathway? 03
(b) How are drugs classified? Briefly explain each classification. 04
(c) What is a ?genetic marker?? Describe its role in Herbal Drug Technology? 07
Q.5 (a) What are organized and unorganized drugs? 03
(b) Describe ?Simultaneous distillation and extraction? with the help of a neat
diagram?
04
(c) What is a glycoside? How are Glycosides classified? List the main groups of
glycosides?
07
OR
Q.5 (a) What are the different types of capsules? Briefly describe each of them? 03
(b) Discuss two drugs isolated from natural resources used in the treatment of
Malaria?
04
(c) Discuss structure, source, isolation and synthesis of Menthol? 07
*************