GTU BE 6th Semester 2163601 Medicinal Chemistry-I Summer 2018 Question Paper

1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE ? SEMESTER-VI (NEW SYLLABUS) EXAMINATION- SUMMER 2018
Subject Code:2163601 Date: 05/05/2018
Subject Name: Medicinal Chemistry-I
Time: 10:30 to 01:00 Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS
Q.1 (a) What Basal Anesthetics & What are its merits? Write one
example with its synthesis.
03
(b) Write the Structural Activity Relationship (SAR) of
Dibenzazepine antidepressants.
04
(c) Write both the pathways of metabolism of Catecholamines with
appropriate structures.
07
Q.2 (a) What are Anticonvulsants? Give one example of Hydantoin
derivative anticonvulsant with structure. Write its Mode of
Action (MOA) & SAR.
03
(b) Write the SAR & MOA of Phenothiazine class of Antipsychotic
drug with proper examples.
04
(c) Write the synthesis of any two drugs: (i).Hydralazine
Hydrochloride, (ii).Atenolol, (iii).Isoxsuprine Hydrochloride, (iv).Sodium Valproate.
07
OR
(c) Write the synthesis of any two drugs: (i). Diazepam, (ii).
Imipramine, (iii). Clofibrate, (iv). Glutethimide
07
Q.3 (a) Write the biosynthesis of Catecholoamines 03
(b) What are General anesthetics & what are its classifications?
Give suitable examples. Write the synthesis of any two drugs.
04
(c) Write the SAR of Adrenergic drugs which contain ?-phenyl
ethylamine as parent structure. Write structures wherever
required.
07
OR
Q.3 (a) Write the biosynthesis & metabolism of Acetylcholine 03
(b) Write the MOA, synthesis & metabolism of any one barbiturate
class of sedative / hypnotic.
04
(c) Write the synthesis of indirectly acting reversible cholinergic
drug- Physostigmine (structure given)07
Q.4 (a) Write a note on Osteoporosis. Mention its causes and give two
examples of Anti osteoporotic drugs.
03
(b) Describe Parkinsonism and write the classifications of
antiparkinsonism agents with examples. Write the metabolism
of antiparkinsonism agent Levodopa.
04
(c) What are the classifications of Adrenergic drugs based on
chemical structures. Give one example with its synthesis in each
class.
07
OR 1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE ? SEMESTER-VI (NEW SYLLABUS) EXAMINATION- SUMMER 2018
Subject Code:2163601 Date: 05/05/2018
Subject Name: Medicinal Chemistry-I
Time: 10:30 to 01:00 Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS
Q.1 (a) What Basal Anesthetics & What are its merits? Write one
example with its synthesis.
03
(b) Write the Structural Activity Relationship (SAR) of
Dibenzazepine antidepressants.
04
(c) Write both the pathways of metabolism of Catecholamines with
appropriate structures.
07
Q.2 (a) What are Anticonvulsants? Give one example of Hydantoin
derivative anticonvulsant with structure. Write its Mode of
Action (MOA) & SAR.
03
(b) Write the SAR & MOA of Phenothiazine class of Antipsychotic
drug with proper examples.
04
(c) Write the synthesis of any two drugs: (i).Hydralazine
Hydrochloride, (ii).Atenolol, (iii).Isoxsuprine Hydrochloride, (iv).Sodium Valproate.
07
OR
(c) Write the synthesis of any two drugs: (i). Diazepam, (ii).
Imipramine, (iii). Clofibrate, (iv). Glutethimide
07
Q.3 (a) Write the biosynthesis of Catecholoamines 03
(b) What are General anesthetics & what are its classifications?
Give suitable examples. Write the synthesis of any two drugs.
04
(c) Write the SAR of Adrenergic drugs which contain ?-phenyl
ethylamine as parent structure. Write structures wherever
required.
07
OR
Q.3 (a) Write the biosynthesis & metabolism of Acetylcholine 03
(b) Write the MOA, synthesis & metabolism of any one barbiturate
class of sedative / hypnotic.
04
(c) Write the synthesis of indirectly acting reversible cholinergic
drug- Physostigmine (structure given)07
Q.4 (a) Write a note on Osteoporosis. Mention its causes and give two
examples of Anti osteoporotic drugs.
03
(b) Describe Parkinsonism and write the classifications of
antiparkinsonism agents with examples. Write the metabolism
of antiparkinsonism agent Levodopa.
04
(c) What are the classifications of Adrenergic drugs based on
chemical structures. Give one example with its synthesis in each
class.
07
OR
2
Q.4 (a) Describe (i). Emetics, (ii). Sedatives & Hypnotics,(iii).
Hyperlipidemia.
03
(b) Write the SAR of Cholinergic drugs. 04
(c) Write the MOA of Mono amino oxidase inhibitor antidepressant
& Tricyclic antidepressant. Give one example in each class.
Write the synthesis of Phenelzine.
07
Q.5 (a) Write one example of antipsychotic alkaloid drug. Write its
MOA.
03
(b) Write a note on Pyridine derivative antihyperlipidemic agent.
Mention one example with its MOA & synthesis.
04
(c) Write the MOA of Antisympathetic drug Propranolol HCl.
Write its synthesis & write the SAR of ?-adrenergic blockers.
07
OR
Q.5 (a) Write the MOA of benzodiazepine class & GABA analogue
antiepileptic drugs. Give one example in each class.
03
(b) What are antihyperlipidemic drugs? What are its classifications?
Write a note on HMG-CoA reductase inhibitor with suitable
examples.
04
(c) Write the MOA, SAR & synthesis of butyrophenone
antipsychotic drug-Haloperdol (structure given)07

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